The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape Supplementary information
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A mechanical bottleneck explains the variation in cup growth during FcγR phagocytosis
Phagocytosis is the process by which cells internalize particulate material, and is of central importance to immunity, homeostasis and development. Here, we study the internalization of immunoglobulin G-coated particles in cells transfected with Fcgamma receptors (FcgammaRs) through the formation of an enveloping phagocytic cup. Using confocal microscopy, we precisely track the location of fluo...
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Phagocytosis is a fascinating process whereby a cell surrounds and engulfs particles such as bacteria and dead cells. This is crucial both for single-cell organisms (as a way of acquiring nutrients) and as part of the immune system (to destroy foreign invaders). This whole process is hugely complex and involves multiple coordinated events such as membrane remodelling, receptor motion, cytoskele...
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The Diaphanous-related formin Dia1 nucleates actin polymerization, thereby regulating cell shape and motility. Mechanisms that control the cellular location of Dia1 to spatially define actin polymerization are largely unknown. In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location. IQGAP1 interacts with Dia1 t...
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Microtubules serve as tracks for vesicular traffic in both phagosome formation and phagosome maturation. In the process of phagosome formation, endomembrane vesicles are delivered to the membrane of the forming phagosomes to supply membrane. This localized endomembrane delivery, referred to as focal exocytosis, facilitates pseudopod extension for the purpose of engulfing large particles. The mi...
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During Fcγ receptor (FcR)-mediated phagocytosis by macrophages, cytoplasm advances over IgG-coated particles by the sequential ligation of FcR in plasma membranes. If FcR signaling was strictly autonomous, then the signals generated during phagocytosis should be proportional to the number of ligated receptors. By measuring FcR-dependent responses to beads coated with various densities of IgG, t...
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تاریخ انتشار 2010